Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity.

ABSTRACT: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim to understand how this relationship fuels cancer cell migration. We show that while glycolysis drives single-cell migration in confining microtracks, fast and slow cells display different migratory sensitivities to glycolysis and oxidative phosphorylation inhibition. Phenotypic sorting of highly and weakly migratory subpopulations (MDA⁺, MDA^-) reveals that more mesenchymal, highly migratory MDA⁺ preferentially use glycolysis while more epithelial, weakly migratory MDA^- utilize mitochondrial respiration. These p

SUBMITTER: Schwager SC 

PROVIDER: S-EPMC9579510 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature