Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases.

ABSTRACT: Systemic autoimmune diseases are characterized by the failure of the immune system to differentiate self from non-self. These conditions are associated with significant morbidity and mortality, and they can affect many organs and systems, having significant clinical heterogeneity. Recent discoveries have highlighted that neutrophils, and in particular the neutrophil extracellular traps that they can release upon activation, can have central roles in the initiation and perpetuation of systemic autoimmune disorders and orchestrate complex inflammatory responses that lead to organ damage. Dysregulation of neutrophil cell death can lead to the modification of autoantigens and their presentation to the adaptive immune system. Furthermore, subsets of neutrophils that seem to be more prevalent in

SUBMITTER: Wigerblad G 

PROVIDER: S-EPMC9579530 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature