Genetically predicted phosphate and cardiovascular disease: A Mendelian randomization study

ABSTRACT:

Background

Extensive epidemiological studies have highlighted the correlation between serum phosphate and cardiovascular diseases. The present study aims to determine whether genetically predicted serum phosphate is causally associated with the distinct subtypes of cardiovascular events through the use of Mendelian randomization (MR) analysis.

Methods

Independent and strongly correlated single-nucleotide polymorphisms (SNPs) for serum phosphate were extracted from publicly available genome-wide association studies. Summary statistics of cardiovascular diseases were derived from large-scale consortiums, including HERMES and FinnGen biobank. MR-Egger, weighted median, inverse variance weighted, pleiotropy residual sum and outlier (MR-PRESSO) methods and MR using robust adju

SUBMITTER:  

PROVIDER: S-EPMC9579538 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature