Characterization of a Hepatitis Outbreak in Children, 2021 to 2022.

ABSTRACT:

Importance

After a cluster of pediatric cases of hepatitis of unknown etiology were identified in Scotland in March 2022, the World Health Organization published an outbreak alert, and more than 1010 probable cases were reported. Some cases progressed to acute liver failure and required liver transplant. Although many patients had positive results for adenovirus on polymerase chain reaction testing from whole blood samples and/or reported recent COVID-19 infection (with or without seropositivity), the precise pathogenesis remains unclear despite the high potential morbidity of this condition.

Objective

To summarize the currently available evidence regarding novel pediatric hepatitis of unknown etiology (or novel hepatitis), encompassing case numbers, testing, management, and

SUBMITTER: Alexander EC 

PROVIDER: S-EPMC9579900 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature