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The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population : A Systematic Review and Dose-Response Meta-analysis.


ABSTRACT:

Background

To what extent the COVID-19 pandemic and its containment measures influenced mental health in the general population is still unclear.

Purpose

To assess the trajectory of mental health symptoms during the first year of the pandemic and examine dose-response relations with characteristics of the pandemic and its containment.

Data sources

Relevant articles were identified from the living evidence database of the COVID-19 Open Access Project, which indexes COVID-19-related publications from MEDLINE via PubMed, Embase via Ovid, and PsycInfo. Preprint publications were not considered.

Study selection

Longitudinal studies that reported data on the general population's mental health using validated scales and that were published before 31 March 2021 were eligible.

Data extraction

An international crowd of 109 trained reviewers screened references and extracted study characteristics, participant characteristics, and symptom scores at each timepoint. Data were also included for the following country-specific variables: days since the first case of SARS-CoV-2 infection, the stringency of governmental containment measures, and the cumulative numbers of cases and deaths.

Data synthesis

In a total of 43 studies (331 628 participants), changes in symptoms of psychological distress, sleep disturbances, and mental well-being varied substantially across studies. On average, depression and anxiety symptoms worsened in the first 2 months of the pandemic (standardized mean difference at 60 days, -0.39 [95% credible interval, -0.76 to -0.03]); thereafter, the trajectories were heterogeneous. There was a linear association of worsening depression and anxiety with increasing numbers of reported cases of SARS-CoV-2 infection and increasing stringency in governmental measures. Gender, age, country, deprivation, inequalities, risk of bias, and study design did not modify these associations.

Limitations

The certainty of the evidence was low because of the high risk of bias in included studies and the large amount of heterogeneity. Stringency measures and surges in cases were strongly correlated and changed over time. The observed associations should not be interpreted as causal relationships.

Conclusion

Although an initial increase in average symptoms of depression and anxiety and an association between higher numbers of reported cases and more stringent measures were found, changes in mental health symptoms varied substantially across studies after the first 2 months of the pandemic. This suggests that different populations responded differently to the psychological stress generated by the pandemic and its containment measures.

Primary funding source

Swiss National Science Foundation. (PROSPERO: CRD42020180049).

SUBMITTER: Salanti G 

PROVIDER: S-EPMC9579966 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population : A Systematic Review and Dose-Response Meta-analysis.

Salanti Georgia G   Peter Natalie N   Tonia Thomy T   Holloway Alexander A   White Ian R IR   Darwish Leila L   Low Nicola N   Egger Matthias M   Haas Andreas D AD   Fazel Seena S   Kessler Ronald C RC   Herrman Helen H   Kieling Christian C   De Quervain Dominique J F DJF   Vigod Simone N SN   Patel Vikram V   Li Tianjing T   Cuijpers Pim P   Cipriani Andrea A   Furukawa Toshi A TA   Leucht Stefan S   Sambo Abdulkadir Usman AU   Onishi Akira A   Sato Akira A   Rodolico Alessandro A   Oliveira Solis Ana Cristina de AC   Antoniou Anastasia A   Kapfhammer Angelika A   Ceraso Anna A   O'Mahony Aoife A   Lasserre Aurélie M AM   Ipekci Aziz Mert AM   Concerto Carmen C   Zangani Caroline C   Igwesi-Chidobe Chinonso C   Diehm Christina C   Demir Dicle Dilay DD   Wang Dongfang D   Ostinelli Edoardo Giuseppe EG   Sahker Ethan E   Beraldi Gabriel Henrique GH   Erzin Gamze G   Nelson Harrison H   Elkis Helio H   Imai Hissei H   Wu Hui H   Kamitsis Ilias I   Filis Ioannis I   Michopoulos Ioannis I   Bighelli Irene I   Hong James S W JSW   Ballesteros Javier J   Smith Katharine A KA   Yoshida Kazufumi K   Omae Kenji K   Trivella Marialena M   Tada Masafumi M   Reinhard Matthias A MA   Ostacher Michael J MJ   Müller Monika M   Jaramillo Nathalia Gonzalez NG   Ferentinos Panagiotis P PP   Toyomoto Rie R   Cortese Samuele S   Kishimoto Sanae S   Covarrubias-Castillo Sergio A SA   Siafis Spyridon S   Thompson Trevor T   Karageorgiou Vasilios V   Chiocchia Virginia V   Zhu Yikang Y   Honda Yukiko Y  

Annals of internal medicine 20221018 11


<h4>Background</h4>To what extent the COVID-19 pandemic and its containment measures influenced mental health in the general population is still unclear.<h4>Purpose</h4>To assess the trajectory of mental health symptoms during the first year of the pandemic and examine dose-response relations with characteristics of the pandemic and its containment.<h4>Data sources</h4>Relevant articles were identified from the living evidence database of the COVID-19 Open Access Project, which indexes COVID-19-  ...[more]

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