A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus marked by eosinophilic infiltration. Cumulative evidence indicates that the risk of EoE involves the complex interplay of both genetic and environmental factors. Because only a few genetic loci have been identified in EoE, the genetic underpinning of EoE remains largely elusive.

Objective

We sought to identify genetic loci associated with EoE.

Methods

Four EoE cohorts were genotyped using the Illumina single nucleotide polymorphism array platform, totaling 1,930 cases and 13,634 controls of European ancestry. Genotype imputation was performed with the Michigan Imputation Server using the Trans-Omics for Precision Medicine reference panel including whole-genome sequencing data

SUBMITTER: Chang X 

PROVIDER: S-EPMC9579995 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature