Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat.

ABSTRACT: Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced stage of DMD and this often leads to an eating disorder such as dysphagia. Dysphagia is caused by multiple etiologies including decreased mastication and swallowing. Therefore, preventing the functional declines of mastication and swallowing in DMD is important to improve the patient's quality of life. In the present study, using a rat model of DMD we generated previously, we performed analyses on the masseter and tongue muscles, both are required for proper eating function. Age-related changes of the masseter and tongue muscle of DMD rats were analyzed morphometrically, histologically,

SUBMITTER: Yamanouchi K 

PROVIDER: S-EPMC9580129 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature