Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications.

ABSTRACT:

Background

Preeclampsia is a pregnancy-related condition that causes high blood pressure and proteinuria after 20 weeks of pregnancy. It is linked to increased maternal mortality, organ malfunction, and foetal development limitation. In this view, there is a need critical to identify biomarkers for the early detection of preeclampsia. The objective of this study is to discover critical genes and explore medications for preeclampsia treatment that may influence these genes.

Methods

Four datasets, including GSE10588, GSE25906, GSE48424 and GSE60438 were retrieved from the Gene Expression Omnibus database. The GSE10588, GSE25906, and GSE48424 datasets were then removed the batch effect using the "sva" R package and merged into a complete dataset. The differentially expressed ge

SUBMITTER: Peng Y 

PROVIDER: S-EPMC9580137 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature