Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer.

ABSTRACT:

Background

Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance. However, the modulatory roles and prognostic value of autophagy regulators in pancreatic cancer have not been identified.

Methods

Transcriptomic data and survival information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to construct a risk score model. Important clinical features were analyzed to generate a nomogram. In addition, we used various algorithms, including ssGSEA, CIBERSORT, XCELL, EPIC, TIMER, and QUANTISEQ, to evaluate the roles of autophagy regulators in the pancreatic cancer immune microenvironment. Furthermore, the mutation landscape was compared be

SUBMITTER: Lu SY 

PROVIDER: S-EPMC9580150 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature