Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC).

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most diagnosed cancers in the world. PCa inevitably progresses to castration-resistant prostate cancer (CRPC) after androgen deprivation therapy treatment, and castration-resistant state means a shorter survival time than other causes. Here we aimed to define castration-dependent and -independent diver genes and molecular pathways in CRPC which are responsible for such lethal metastatic events.

Methods

By employing digital gene expression (DGE) profiling, the alterations of the epididymal gene expression profile in the mature and bilateral castrated rat were explored. Then we detect and characterize the castration-dependent and -independent genes and pathways with two data set of CPRC-associated gene expression profiles publicly

SUBMITTER: Li Y 

PROVIDER: S-EPMC9580185 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature