Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study.

ABSTRACT:

Background

Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-formylmethionine is associated with increases in metabolomic shift-related metabolites and increases in 28-day mortality.

Methods

We performed metabolomics analyses on plasma from the 428-subject Correction of Vitamin D Deficiency in Critically Ill Patients trial (VITdAL-ICU) cohort and the 90-subject Brigham and Women's Hospital Registry of Critical Illness (RoCI) cohort. In the VITdAL-ICU cohort, we analyzed 983 metabolites at Intensive Care Unit (ICU) admission, day 3, and 7. In the RoCI cohort, we analyzed 411 metabolites at ICU admission. The association

SUBMITTER: Sigurdsson MI 

PROVIDER: S-EPMC9580206 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature