Atypical hemolytic uremic syndrome triggered by mRNA vaccination against SARS-CoV-2: Case report.

ABSTRACT: Atypical hemolytic uremic syndrome (aHUS), also called complement-mediated hemolytic uremic syndrome (CM-HUS), is a rare disease caused by dysregulation in the alternative complement activation pathway. It is a life-threatening condition causing ischemia of a number of organs, and it typically causes acute kidney injury. This disorder may be triggered by various factors including viral or bacterial infections, pregnancy, surgery, and injuries. In about 60% of cases, the genetic origin of the disease can be identified-commonly mutations affecting complementary factor H and MCP protein. Eculizumab, a monoclonal antibody to the C5 component of the complement, represents the current effective treatment.We describe a case of a young woman with a previous history of polyvalent allergies, who dev

SUBMITTER: Rysava R 

PROVIDER: S-EPMC9580272 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature