Systematic design of cell membrane coating to improve tumor targeting of nanoparticles.

ABSTRACT: Cell membrane (CM) coating technology is increasingly being applied in nanomedicine, but the entire coating procedure including adsorption, rupture, and fusion is not completely understood. Previously, we showed that the majority of biomimetic nanoparticles (NPs) were only partially coated, but the mechanism underlying this partial coating remains unclear, which hinders the further improvement of the coating technique. Here, we show that partial coating is an intermediate state due to the adsorption of CM fragments or CM vesicles, the latter of which could eventually be ruptured under external force. Such partial coating is difficult to self-repair to achieve full coating due to the limited membrane fluidity. Building on our understanding of the detailed coating process, we develop a gener

SUBMITTER: Liu L 

PROVIDER: S-EPMC9580449 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature