Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals.

ABSTRACT:

Background

Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT_2AR) binding. However, the association between psilocybin-induced mystical-type experiences and subsequent changes in trait mindfulness remains unexplored, as does the association between pre-drug trait mindfulness and 5-HT_2AR binding in the healthy brain.

Aim

We evaluated whether psilocybin induced lasting increases in trait mindfulness in healthy volunteers, and whether the mystical-type experience was associated with this increase. We further examined the association between pre-d

SUBMITTER: Sondergaard A 

PROVIDER: S-EPMC9580465 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature