Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

ABSTRACT: Central nervous system (CNS) damage by galactic cosmic ray radiation is a major health risk for human deep space exploration. Simulated galactic cosmic rays or their components, especially high Z-high energy particles such as ⁵⁶Fe ions, cause neurodegeneration and neuroinflammation in rodent models. CNS damage can be partially mediated by the blood-brain barrier, which regulates systemic interactions between CNS and the rest of the body. Astrocytes are major cellular regulators of blood-brain barrier permeability that also modulate neuroinflammation and neuronal health. However, astrocyte roles in regulating CNS and blood-brain barrier responses to space radiation remain little understood, especially in human tissue analogs. In this work, we used a novel high-throughput human or

SUBMITTER: Verma SD 

PROVIDER: S-EPMC9580499 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature