ChanFAD: A Functional Annotation Database for Ion Channels.

ABSTRACT: Ion channels are integral membrane protein complexes critical for regulation of membrane potential, cell volume, and other signaling events. As complex molecular assemblies with many interacting partners, ion channels have multiple structural and functional domains. While channel sequence and functional data are readily available across multiple online resources, there is an unmet need for functional annotation directly relating primary sequence information, 2D interactions, and three-dimensional protein structure. To this end, we present ChanFAD (Channel Functional Annotation Database), to provide the research community with a centralized resource for ion channel structure and functional data. ChanFAD provides functional annotation of PDB structures built on the National Center for Biotec

SUBMITTER: Castro EV 

PROVIDER: S-EPMC9580856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature