Mast Cell-Dependent CD8⁺ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in Apc^Min/+ Mice.

ABSTRACT: The presence of mast cells in some human colorectal cancers is a positive prognostic factor, but the basis for this association is incompletely understood. Here, we found that mice with a heterozygous mutation in the adenomatous polyposis coli gene (Apc^Min/+) displayed reduced intestinal tumor burdens and increased survival in a chemokine decoy receptor, ACKR2-null background, which led to discovery of a critical role for mast cells in tumor defense. ACKR2^-/-Apc^Min/+ tumors showed increased infiltration of mast cells, their survival advantage was lost in mast cell-deficient ACKR2^-/-SA^-/-Apc^Min/+ mice as the tumors grew rapidly, and adoptive transfer of mast cells restored control of tumor growth. Mast cells from ACKR2

SUBMITTER: Bodduluri SR 

PROVIDER: S-EPMC9580996 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature