EPIphany-A Platform for Analysis and Visualization of Peptide Immunoarray Data.

ABSTRACT: Antibodies are critical effector molecules of the humoral immune system. Upon infection or vaccination, populations of antibodies are generated which bind to various regions of the invading pathogen or exogenous agent. Defining the reactivity and breadth of this antibody response provides an understanding of the antigenic determinants and enables the rational development and assessment of vaccine candidates. High-resolution analysis of these populations typically requires advanced techniques such as B cell receptor repertoire sequencing, mass spectrometry of isolated immunoglobulins, or phage display libraries that are dependent upon equipment and expertise which are prohibitive for many labs. High-density peptide microarrays representing diverse populations of putative linear epitopes (im

SUBMITTER: Parker Cates Z 

PROVIDER: S-EPMC9581008 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature