A Novel Calibration Step in Gene Co-Expression Network Construction.

ABSTRACT: High-throughput technologies such as DNA microarrays and RNA-sequencing are used to measure the expression levels of large numbers of genes simultaneously. To support the extraction of biological knowledge, individual gene expression levels are transformed to Gene Co-expression Networks (GCNs). In a GCN, nodes correspond to genes, and the weight of the connection between two nodes is a measure of similarity in the expression behavior of the two genes. In general, GCN construction and analysis includes three steps; 1) calculating a similarity value for each pair of genes 2) using these similarity values to construct a fully connected weighted network 3) finding clusters of genes in the network, commonly called modules. The specific implementation of these three steps can significantly impac

SUBMITTER: Aghaieabiane N 

PROVIDER: S-EPMC9581019 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature