BRANEart: Identify Stability Strength and Weakness Regions in Membrane Proteins.

ABSTRACT: Understanding the role of stability strengths and weaknesses in proteins is a key objective for rationalizing their dynamical and functional properties such as conformational changes, catalytic activity, and protein-protein and protein-ligand interactions. We present BRANEart, a new, fast and accurate method to evaluate the per-residue contributions to the overall stability of membrane proteins. It is based on an extended set of recently introduced statistical potentials derived from membrane protein structures, which better describe the stability properties of this class of proteins than standard potentials derived from globular proteins. We defined a per-residue membrane propensity index from combinations of these potentials, which can be used to identify residues which strongly contribu

SUBMITTER: Basu S 

PROVIDER: S-EPMC9581023 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature