Unknown

Dataset Information

0

Case report: CD19-directed CAR-T cell therapy combined with BTK inhibitor and PD-1 antibody against secondary central nervous system lymphoma.


ABSTRACT: Current therapeutic strategies for central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) are extremely limited. Secondary central nervous system lymphoma (SCNSL) also shows a grave prognosis and high mortality. This report describes a young female patient with DLBCL and CNS relapse who received low-dose CD19-directed chimeric antigen receptor T (CAR-T) cell therapy followed with Bruton's tyrosine kinase inhibitor and programmed cell death protein 1 antibody after several lines of chemotherapy. However, limited reports on CAR-T cell therapy are applied for SCNSL, particularly those in combination with targeted agents. The current treatment combination for this case provides a new regimen for CNS relapse from DLBCL.

Clinical trial registration

ClinicalTrials.gov number, NCT04666168.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9581047 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

altmetric image

Publications

Case report: CD19-directed CAR-T cell therapy combined with BTK inhibitor and PD-1 antibody against secondary central nervous system lymphoma.

Zhang Wenqi W   Huang Chen C   Liu Ruixia R   Zhang Huichao H   Li Weijing W   Yin Shaoning S   Wang Lianjing L   Liu Wei W   Liu Lihong L  

Frontiers in immunology 20221005


Current therapeutic strategies for central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) are extremely limited. Secondary central nervous system lymphoma (SCNSL) also shows a grave prognosis and high mortality. This report describes a young female patient with DLBCL and CNS relapse who received low-dose CD19-directed chimeric antigen receptor T (CAR-T) cell therapy followed with Bruton's tyrosine kinase inhibitor and programmed cell death protein 1 antibody after several  ...[more]

Similar Datasets

| S-EPMC9437350 | biostudies-literature
| S-EPMC9811622 | biostudies-literature
| S-EPMC8282870 | biostudies-literature
| S-EPMC8085484 | biostudies-literature
| S-EPMC9850100 | biostudies-literature
| S-EPMC8945630 | biostudies-literature
| S-EPMC10633964 | biostudies-literature
| S-EPMC11471030 | biostudies-literature
| S-EPMC7479945 | biostudies-literature
| S-EPMC10864416 | biostudies-literature