Identification of Biomarkers Controlling Cell Fate In Blood Cell Development.

ABSTRACT: A blood cell lineage consists of several consecutive developmental stages starting from the pluri- or multipotent stem cell to a state of terminal differentiation. Despite their importance for human biology, the regulatory pathways and gene networks that govern these differentiation processes are not yet fully understood. This is in part due to challenges associated with delineating the interactions between transcription factors (TFs) and their corresponding target genes. A possible step forward in this case is provided by the increasing amount of expression data, as a basis for linking differentiation stages and gene activities. Here, we present a novel hierarchical approach to identify characteristic expression peak patterns that global regulators excert along the differentiation path of

SUBMITTER: Nazarieh M 

PROVIDER: S-EPMC9581055 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature