The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.

ABSTRACT: Long-term blood pressure variability (BPV) is a risk factor for cardiovascular diseases, dementia, and stroke. However, its genetic architecture is not fully understood. This study aims to explore its genetic factors and provide more evidence on the mechanisms and further pathological study of BPV. The genome-wide association study (GWAS) is based on the UK Biobank cohort. There were four data collection rounds from 2006 to 2020, and 9370 participants with more than three blood pressure measurements were included. They had a median age of 55 and a male percentage of 50.1%. The phenotypes (BPV) were calculated by four methods and the genetic data contains 6 884 260 single nucleotide polymorphisms (SNPs) after imputation and quality control. A linear regression model was performed with adjus

SUBMITTER: Jia P 

PROVIDER: S-EPMC9581094 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature