Vitamin D levels and Vitamin D-related gene polymorphisms in Chinese children with type 1 diabetes.

ABSTRACT: Low vitamin D levels may play a role in type 1 diabetes (T1D) susceptibility. Since 25(OH)D synthesis is genetically regulated, single nucleotide polymorphisms (SNPs) of important genes have also been shown to modulate the risk of T1D, so this study aimed to investigate the relationship between five SNPs in CYP2R1, DHCR7, CYP24A1, VDR genes, serum 25(OH)D levels and T1D in Chinese children. This case-control study included 141 T1D patients and 200 age-matched healthy children.25 (OH) D concentration was determined, genotyping was performed by High resolution melting (HRM). There was a significant difference in the prevalence of vitamin D deficiency, insufficiency, and sufficiency between T1D and healthy controls. (χ ² = 10.86, p = 0.004), however no evidence of the

SUBMITTER: Chen X 

PROVIDER: S-EPMC9581124 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature