Meta-analysis of active tuberculosis gene expression ascertains host directed drug targets.

ABSTRACT: Multi-drug resistant tuberculosis still remains a major public health crisis globally. With the emergence of newer active tuberculosis disease, the requirement of prolonged treatment time and adherence to therapy till its completion necessitates the search of newer therapeutics, targeting human host factors. The current work utilized statistical meta-analysis of human gene transcriptomes of active pulmonary tuberculosis disease obtained from six public datasets. The meta-analysis resulted in the identification of 2038 significantly differentially expressed genes (DEGs) in the active tuberculosis disease. The gene ontology (GO) analysis revealed that these genes were major contributors in immune responses. The pathway enrichment analyses identified from various human canonical pathways are

SUBMITTER: Ponnusamy N 

PROVIDER: S-EPMC9581169 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature