Integration of ATAC-seq and RNA-seq analysis identifies key genes affecting intramuscular fat content in pigs.

ABSTRACT: Meat quality is one of the most important economic traits in pig breeding and production, and intramuscular fat (IMF) content is the major factor in improving meat quality. The IMF deposition in pigs is influenced by transcriptional regulation, which is dependent on chromatin accessibility. However, how chromatin accessibility plays a regulatory role in IMF deposition in pigs has not been reported. Xidu black is a composite pig breed with excellent meat quality, which is an ideal research object of this study. In this study, we used the assay for transposase-accessible chromatin using sequencing (ATAC-seq) and RNA sequencing (RNA-seq) analysis to identify the accessible chromatin regions and key genes affecting IMF content in Xidu black pig breed with extremely high and low IMF content. Fi

SUBMITTER: Xu Z 

PROVIDER: S-EPMC9581296 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature