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Studies toward synthesis of the core skeleton of spiroaspertrione A.

ABSTRACT: Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.

SUBMITTER: Shen ZH

PROVIDER: S-EPMC9581311 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Studies toward synthesis of the core skeleton of spiroaspertrione A.

Shen Zhong-Hui ZH Lu Si-Yuan SY Zheng Jing-Yun JY Zhang Xiang-Zhi XZ Peng Jin-Bao JB Ma Ai-Jun AJ

Frontiers in chemistry 20221005

Bioassay-guided isolation of spiroaspertrione A from cultures of <i>Aspergillus sp</i>. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant <i>Staphylococcus aureus</i> by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed. ...[more]

PMID: 36277342

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