Studies toward synthesis of the core skeleton of spiroaspertrione A

ABSTRACT: Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.

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PROVIDER: S-EPMC9581311 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature