Blood transcriptome analysis: Ferroptosis and potential inflammatory pathways in post-traumatic stress disorder.

ABSTRACT:

Background

Transcriptome-wide analysis of peripheral blood in post-traumatic stress disorder (PTSD) indicates widespread changes in immune-related pathways and function. Ferroptosis, an iron-dependent regulated cell death, is closely related to oxidative stress. However, little is known as to whether ferroptosis plays a role in PTSD.

Methods

We conducted a comprehensive analysis of combined data from six independent peripheral blood transcriptional studies in the Gene Expression Omnibus (GEO) database, covering PTSD and control individuals. Differentially expressed genes (DEGs) were extracted by comparing PTSD patients with control individuals, from which 29 ferroptosis-related genes (FRGs) were cross-matched and obtained. The weighted gene co-expression network analysis (WG

SUBMITTER: Zhu J 

PROVIDER: S-EPMC9581323 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature