Effects of Hyperthyroidism on Venous Thromboembolism: A Mendelian Randomization Study.

ABSTRACT:

Objective

Observational studies show the correlation between thyroid dysfunction and risk of venous thromboembolism. However, the causal effects remain uncertain. Our study was conducted to evaluate whether thyroid function and dysfunction were causally linked to the risk of venous thromboembolism.

Methods

Publicly available summary data of thyrotropin (TSH) and free thyroxine (FT4), hypothyroidism, and hyperthyroidism were obtained from the ThyroidOmics Consortium and the UK Biobank. With single nucleotide polymorphisms (SNPs) as instrumental variables, the casual effects of genetically predicted TSH and FT4 and hypo- and hyperthyroidism on venous thromboembolism outcome were estimated through Mendelian randomization analysis methods (inverse variance weighted (IVW), MR-Egg

SUBMITTER: Han F 

PROVIDER: S-EPMC9581675 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature