The Effect of Bevacizumab and Propranolol on Nasal Polyposis.

ABSTRACT:

Objective

This study aims to evaluate the effects of bevacizumab and propranolol from the point of view of a possible antiangiogenic effect in a model of primary nasal polyp (NP) tissue culture.

Methods

NP samples of 21 patients and normal healthy nasal mucosa samples of 7 patients were cultured. Samples were divided into four groups as follows (healthy nasal mucosa, NP without any treatment, NP treated with propranolol, NP treated with bevacizumab). Cultured tissues were formalin fixed and paraffin embedded. Tissue sections and immunohistochemical VEGF-A, angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2) expressions were evaluated. ELISA was also performed for each one of them.

Results

Both propranolol and bevacizumab significantly decreased the expressions of VEGF-

SUBMITTER: Olgun Y 

PROVIDER: S-EPMC9581690 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature