Homologous peptides derived from influenza A, B and C viruses induce variable CD8⁺ T cell responses with cross-reactive potential.

ABSTRACT:

Objective

Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP_265-273, and its IBV and ICV homologues, presented by HLA-A*03:01 molecule expressed in ~ 4% of the global population (~ 300 million people).

Methods

We assessed the magnitude (tetramer staining) and quality of the CD8⁺ T cell response (intracellular cytokine staining) towards NP_265-IAV and described the T cell receptor (TCR) repertoire used to recognise this immunodominant epitope. We next assessed the immunogenicity of NP_265-IAV homologue peptides from IBV and ICV and the ability of CD8⁺

SUBMITTER: Nguyen AT 

PROVIDER: S-EPMC9581725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature