A wheat resistosome defines common principles of immune receptor channels.

ABSTRACT: Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses¹. Indirect recognition of a pathogen effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing NLR (CNL) ZAR1 induces the formation of a large hetero-oligomeric protein complex, termed the ZAR1 resistosome, which functions as a calcium channel required for ZAR1-mediated immunity^2-4. Whether the resistosome and channel activities are conserved among plant CNLs remains unknown. Here we report the cryo-electron microscopy structure of the wheat CNL Sr35⁵ in complex with the effector AvrSr35⁶ of the wheat stem rust pathogen. Direct effector binding to the leucine-rich repeats of Sr35 results in the

SUBMITTER: Forderer A 

PROVIDER: S-EPMC9581773 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature