Effect of corticosteroids in patients with COVID-19: a Bayesian network meta-analysis.

ABSTRACT:

Objectives

We sought to perform a network meta-analysis to compare the safety and efficacy of the systemic administration of corticosteroids for the treatment of COVID-19.

Methods

A Bayesian network meta-analysis was performed to combine the direct and indirect evidence. The surface under the cumulative ranking curve was obtained to estimate the ranking probability of the treatment agents for each outcome. The efficacy outcome was 28-day all-cause mortality. The safety outcome was serious adverse events.

Results

A total of 16 trials with 2992 patients comparing four treatments (dexamethasone, hydrocortisone, methylprednisolone, and placebo) were identified. Direct analysis showed that corticosteroids were associated with a reduced risk of 28-day mortality compared wit

SUBMITTER: Wang X 

PROVIDER: S-EPMC9581790 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature