Fabrication of Customizable Intraplaque Hemorrhage Phantoms for Magnetic Resonance Imaging.

ABSTRACT:

Purpose

Magnetic resonance (MR) imaging detection of methemoglobin, a molecular marker of intraplaque hemorrhage (IPH), in atherosclerotic plaque is a promising method of assessing stroke risk. However, the multicenter imaging studies required to further validate this technique necessitate the development of IPH phantoms to standardize images acquired across different scanners. This study developed a set of phantoms that modeled methemoglobin-laden IPH for use in MR image standardization.

Procedures

A time-stable material mimicking the MR properties of methemoglobin in IPH was created by doping agarose hydrogel with gadolinium and sodium alginate. This material was used to create a phantom that consisted of 9 cylindrical IPH sites (with sizes from 1 to 8 mm). Anatomical repl

SUBMITTER: Bomben MA 

PROVIDER: S-EPMC9581813 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature