Early-life gut microbiota and attention deficit hyperactivity disorder in preadolescents.

ABSTRACT:

Background

Gut microbiota maturation coincides with nervous system development. Cross-sectional data suggest gut microbiota of individuals with and without attention deficit hyperactivity disorder (ADHD) differs. We hypothesized that infant gut microbiota composition is associated with later ADHD development in our on-going birth cohort study, WHEALS.

Methods

Gut microbiota was profiled using 16S ribosomal RNA and the internal transcribed spacer region 2 (ITS2) sequencing in stool samples from 1 month and 6 months of age. ADHD was defined by parent-reported or medical record doctor diagnosis at age 10.

Results

A total of 314 children had gut microbiota and ADHD data; 59 (18.8%) had ADHD. After covariate adjustment, bacterial phylogenetic diversity (p = 0.017) and bact

SUBMITTER: Cassidy-Bushrow AE 

PROVIDER: S-EPMC9582043 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature