A pyroptosis-associated gene risk model for predicting the prognosis of triple-negative breast cancer.

ABSTRACT:

Background

Pyroptosis is a novel identified form of inflammatory cell death that is important in the development and progression of various diseases, including malignancies. However, the relationship between pyroptosis and triple-negative breast cancer (TNBC) is still unclear. Therefore, we started to investigate the potential prognostic value of pyroptosis-associated genes in TNBC.

Methods

Thirty-three genes associated with pyroptosis were extracted from previous publications, 30 of which were identified in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort. On the basis of the 30 pyroptosis-related genes, patients with TNBC were divided into three subtypes through unsupervised cluster analysis. The prognostic value of each pyroptosis-associa

SUBMITTER: Qiu P 

PROVIDER: S-EPMC9582146 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature