Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.

ABSTRACT: Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are few, the KCNJ6 gene is a promising target for investigating genetic factors that contribute to pain and analgesia response. This is the first association study on polymorphisms in KCNJ6 and response to methadone for pain management in advanced cancer. Fifty-four adult patients with advanced cancer were recruited across two study sites in a prospective, open label, dose individualisation study. Significant associations have been previously shown for rs2070995 and opioid response in opioid substitution therapy for heroin addiction and studies in chronic pain,

SUBMITTER: Ozberk D 

PROVIDER: S-EPMC9582209 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature