Association of cannabis use disorder with cardiovascular diseases: A two-sample Mendelian randomization study.

ABSTRACT:

Background

The use of cannabis has increased globally due to more regions decriminalizing marijuana use for therapeutic and recreational aims. Several observational studies have revealed that cannabis use is associated with an increased risk of adverse cardiovascular pathologies and diseases. Nevertheless, the causal associations between cannabis use and cardiovascular diseases remain unclear. Hence, we performed single-variable and multivariable Mendelian randomization (MR) to evaluate the association between cannabis use disorder and various cardiovascular diseases.

Materials and methods

Summary statistics were collected from the largest-to-date genome-wide association studies (GWAS) of cannabis use disorder. The 12 SNPs for cannabis use disorder were used as instrumental

SUBMITTER: Chen M 

PROVIDER: S-EPMC9582269 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature