Systemic triplet therapy for metastatic hormone-sensitive prostate cancer: A systematic review and network meta-analysis.

ABSTRACT: Purpose: To perform a systematic review and network meta-analysis to compare the efficacy and safety of currently available docetaxel-based systemic triplet therapies for metastatic hormone-sensitive prostate cancer (mHSPC). Methods: We searched for eligible publications in PubMed, Embase, and Cochrane CENTRAL. Improvements in overall survival (OS) and radiographic progression-free time (rPFS) were compared indirectly using network meta-analysis and evaluated using the surface under the cumulative ranking curve (SUCRA). Other secondary endpoints, such as time to castration-resistant prostate cancer and/or adverse events (AEs), were also compared and evaluated. Results: Five trials were selected and analyzed using a network meta-analysis. Compared to androgen deprivatio

SUBMITTER: Jian T 

PROVIDER: S-EPMC9582339 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature