DNA methylation regulator-mediated modification pattern defines tumor microenvironment immune infiltration landscape in colon cancer.

ABSTRACT: Emerging evidence implies a non-negligible role of DNA methylation in tumor immunity, however, its comprehensive impact on tumor microenvironment (TME) formation and immune activation remains unclear. In this study, we integrated 24 DNA methylation regulators among 754 colon cancer patients to distinguish different modification patterns via an unsupervised clustering method, and explore their TME immune characteristics. Three DNA methylation modification patterns with distinct prognosis and biological behaviors were identified, consistent with three known phenotypes of immune-inflamed, immune-excluded, and immune-desert. We then determined a DNA methylation gene signature and constructed a DNA methylation score (DMS) to quantify modification patterns individually through principal c

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9582351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature