Aging and hypertension in kidney function decline: A 10 year population-based study.

ABSTRACT:

Background

Aging is associated with a physiological decline in kidney function (KFD). In this study, we aimed to describe the impact of age on the rate of KFD and its interplay with risk factors for chronic kidney disease (CKD), considering mainly hypertension (HT), in the general population.

Materials and methods

Participants of European descent, aged 35-75, were recruited from a populational cohort in Lausanne, Switzerland. Participants with a 10 year follow-up were selected. KFD was defined as the difference in estimated glomerular filtration rate (eGFR) between baseline and follow-up, divided by the observation period. Multivariate linear regressions were used with KFD as the outcome and age as the main predictor. HT was tested as a modifying factor.

Results

We in

SUBMITTER: Jaques DA 

PROVIDER: S-EPMC9582457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature