Clinical Significance of Major Angiogenesis-Related Effectors in Patients with Metastatic Breast Cancer Treated with Trastuzumab-Based Regimens.

ABSTRACT:

Purpose

Angiogenesis is a crucial phenomenon in the development and progression of breast cancer (BC), but the clinical significance of angiogenesis-related proteins in metastatic BC remains unknown. This study investigates the prognostic value of vascular endothelial growth factor receptors 1, 2, 3 (VEGFR1, VEGFR2, VEGFR3) as well as vascular endothelial growth factors A and C (VEGFA and VEGFC) in metastatic BC patients treated with trastuzumab-based regimens.

Materials and methods

Two hundred female patients were included. Protein and mRNA expression of the studied angiogenesis-related factors were evaluated by immunohistochemistry and quantitative polymerase chain reaction, respectively.

Results

High expression of VEGFA, VEGFC, VEGFR1, VEGFR2, and VEGFR3 in the tum

SUBMITTER: Kourea HP 

PROVIDER: S-EPMC9582468 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature