Aberrant DNA Methylation Maker for Predicting Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasms.

ABSTRACT:

Purpose

This study aimed to investigate whether MOS methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms.

Materials and methods

From 2012 to 2017, 294 patients were prospectively enrolled after endoscopic resection of gastric dysplasia (n=171) or early gastric cancer (n=123). When Helicobacter pylori was positive, eradication therapy was performed. Among them, 124 patients completed the study protocol (follow-up duration > 3 years or development of metachronous recurrence during the follow-up). Methylation levels of MOS were measured at baseline using quantitative MethyLight assay from the antrum.

Results

Median follow-up duration was 49.9 months. MOS methylation levels at baseline were not different b

SUBMITTER: Shin CM 

PROVIDER: S-EPMC9582476 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature