Comparing the efficacy of different antibiotic regimens on osteomyelitis: A network meta-analysis of animal studies.

ABSTRACT:

Background

Despite the surge in the number of antibiotics used to treat preclinical osteomyelitis (OM), their efficacy remains inadequately assessed.

Objective

To establish network comparisons on the efficacy of antibiotic regimens on OM in animal studies.

Methods

PubMed, Embase, Web of Science, and The Cochrane Library were searched from inception to March 2022 for relevant articles. Odds ratios (ORs) were generated for dichotomous variants, and the standard mean difference (SMD) was calculated for constant variables. The predominant outcomes were the effective rate of sterility, also known as sterility rates, as well as the bacterial counts at the end of the experiments and antibiotic concentrations in serum or bone. All the network meta-analyses were performed usin

SUBMITTER: Shi X 

PROVIDER: S-EPMC9582527 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature