A universal model of electrochemical safety limits in vivo for electrophysiological stimulation.

ABSTRACT: Electrophysiological stimulation has been widely adopted for clinical diagnostic and therapeutic treatments for modulation of neuronal activity. Safety is a primary concern in an interventional design leveraging the effects of electrical charge injection into tissue in the proximity of target neurons. While modalities of tissue damage during stimulation have been extensively investigated for specific electrode geometries and stimulation paradigms, a comprehensive model that can predict the electrochemical safety limits in vivo doesn't yet exist. Here we develop a model that accounts for the electrode geometry, inter-electrode separation, material, and stimulation paradigm in predicting safe current injection limits. We performed a parametric investigation of the stimulation limits i

SUBMITTER: Vatsyayan R 

PROVIDER: S-EPMC9582612 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature