Pan-cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis.

ABSTRACT:

Background

Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open chromatin regions is lower than that in flanking regions because of the higher accessibility of DNA repair machinery. However, in several cancer types, open chromatin regions show an increased local density of mutations in activated regulatory regions. Although the mutation distribution within open chromatin regions in cancer cells has been investigated, only few studies have focused on their functional implications in cancer. To reveal the impact of highly mutated open chromatin regions on cancer, we investigated the association between mutations in open chromatin regions and their possible functions.

Methods

Whole-genome sequencing data of 18 c

SUBMITTER: Kikutake C 

PROVIDER: S-EPMC9582691 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature