Identification of a combined apoptosis and hypoxia gene signature for predicting prognosis and immune infiltration in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most common malignant tumor worldwide. Apoptosis and hypoxia are involved in the progression of BC, but reliable biomarkers for these have not been developed. We hope to explore a gene signature that combined apoptosis and hypoxia-related genes (AHGs) to predict BC prognosis and immune infiltration.

Methods

We collected the mRNA expression profiles and clinical data information of BC patients from The Cancer Genome Atlas database. The gene signature based on AHGs was constructed using the univariate Cox regression, least absolute shrinkage and selection operator, and multivariate Cox regression analysis. The associations between risk scores, immune infiltration, and immune checkpoint gene expression were studied using single-sample gene s

SUBMITTER: Ren X 

PROVIDER: S-EPMC9582692 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature