Association between antibiotic consumption and colon and rectal cancer development in older individuals: A territory-wide study.

ABSTRACT:

Background

Antibiotics may alter colorectal cancer (CRC) risk due to gut dysbiosis. We aimed to study the specific and temporal effects of various antibiotics on CRC development in older individuals.

Methods

This was a territory-wide retrospective cohort study. Subjects aged 60 years and older who did not have CRC diagnosed on screening/diagnostic colonoscopy diagnosed between 2005 and 2013 were recruited. Exclusion criteria were history of CRC, colectomy, inflammatory bowel disease, and CRC diagnosed within 6 months of index colonoscopy. Exposure was use of any antibiotics up to 5 years before colonoscopy. The primary outcomes were CRC diagnosed >6 m after colonoscopy. Covariates were patient demographics, history of colonic polyps/polypectomy, concomitant medication use (N

SUBMITTER: Cheung KS 

PROVIDER: S-EPMC9582694 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature