Whole-genome analysis of carbapenem-resistant Acinetobacter baumannii from clinical isolates in Southern Thailand.

ABSTRACT: The worldwide spread of carbapenem-resistant Acinetobacter baumannii (CRAB) has become a healthcare challenge for some decades. To understand its molecular epidemiology in Southern Thailand, we conducted whole-genome sequencing (WGS) of 221 CRAB clinical isolates. A comprehensive bioinformatics analysis was performed using several tools to assemble, annotate, and identify sequence types (STs), antimicrobial resistance (AMR) genes, mobile genetic elements (MGEs), and virulence genes. ST2 was the most prevalent ST in the CRAB isolates. For the detection of AMR genes, almost all CRAB isolates carried the bla _OXA-23 gene, while certain isolates harbored the bla _NDM-1 or bla _IMP-14 genes. Also, various AMR genes were observed in these

SUBMITTER: Chukamnerd A 

PROVIDER: S-EPMC9582705 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature