T cell kinetics reveal expansion of distinct lung T cell subsets in acute versus in resolved influenza virus infection.

ABSTRACT: Influenza virus infection is restricted to airway-associated tissues and elicits both cellular and humoral responses ultimately resulting in generation of memory cells able to initiate a rapid immune response against re-infections. Resident memory T cells confer protection at the site of infection where lung-resident memory T cells are important for protecting the host against homologous and heterologous influenza virus infections. Mapping kinetics of local and systemic T cell memory formation is needed to better understand the role different T cells have in viral control and protection. After infecting BALB/c mice with influenza virus strain A/Puerto Rico/8/1934 H1N1 the main proportion of activated T cells and B cells expressing the early activation marker CD69 was detected in lungs and

SUBMITTER: Eriksson M 

PROVIDER: S-EPMC9582761 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature